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NCT06820281 · ClinicalTrials.gov record · last posted 2026-08-10

Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes

Name: Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes — clinical trial record (NCT06820281)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: TIRTLE2

StatusRecruiting

PhasePhase 2

SponsorVictor Chang Cardiac Research Institute

Started2026-07-07

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

This study will examine the effects of Tirzepatide (TZP), a glucagon-like peptide 1 (GLP1) - gastric inhibitory peptide (GIP) co-agonist, on metabolism in type 1 diabetes (T1D). Research participants with T1D will undergo measures of insulin sensitivity, and hormone levels post-meal, post-hypoglycemia and during the overnight period. These measures will be performed prior to, and after 6 weeks of treatment with TZP or placebo.

Protocol amendment history 1 change detected by DataLookout

2026-08-11

Recruitment opened

Trial Details

NCT Number	NCT06820281
Lead Sponsor	Victor Chang Cardiac Research Institute
Conditions	Type 1 Diabetes Mellitus
Enrollment	44 participants
Start Date	2026-07-07
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-10