Clinical Trial

The Effects of Iron Treatment on Malaria and Measles Vaccine Response in Kenyan Infants With Iron Deficiency

Not Yet Recruiting
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Summary
Malaria and iron deficiency cause a significant burden of disease in Africa. Iron deficiency (ID) might affect immune responses to vaccination. In this double-blind randomized controlled trial, we aim to assess: (1) whether ID impairs R21/Matrix-M and measles (MR) vaccine response, (2) whether iron treatment at time of vaccination improves vaccine response.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-02-04; most recent amendment 2025-12-19.
Trial Details
NCT Number NCT06816524
Lead Sponsor Nicole Stoffel
Collaborators: Jomo Kenyatta University of Agriculture and Technology, University of Oxford - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Radboud University Medical Center, National Institute for Public Health and the Environment (RIVM)
Conditions Iron Deficiencies
Enrollment 324 participants
Start Date 2026-01-05
Primary Completion 2027-12-31 (estimated)
Study Completion 2028-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-26