Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery

Postoperative ileus (POI) is a common complication after abdominal surgery, causing symptoms like nausea, vomiting, abdominal distension, and delayed passage of flatus and stool. Management remains challenging, with limited pharmacological options available. Prucalopride, a selective serotonin 5-HT4 receptor agonist, has shown promise in accelerating gastrointestinal recovery after surgery. However, the optimal timing and dosing for preventing POI remains unclear. Higher doses may provide more potent prokinetic effects in the postoperative setting. his study investigates if higher doses of prucalopride (4 mg) improve bowel function return and hospital stay in elective colorectal surgery patients compared to standard doses and placebo.

NCT Number	NCT06816407
Lead Sponsor	Future University in Egypt
Conditions	Post-Op Complication
Enrollment	180 participants
Start Date	2025-03-02
Primary Completion	2025-05 (estimated)
Study Completion	2025-05 (estimated)
Updated on ClinicalTrials.gov	2025-03-19