Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment

Gynecological cancers, including those affecting the ovaries, uterus, and cervix, represent a significant health burden for women. While survival rates have improved, many women experience chronic pelvic pain secondary to cancer treatment, especially radiotherapy and chemotherapy. This treatment-induced pelvic pain can be of difficult management and significantly affects patients' quality of life. In our experience, ozone therapy has emerged as a promising complementary treatment for pain relief in patients with chronic diseases, including side effects of cancer treatment. However, the genetic and epigenetic mechanisms influencing its effectiveness have not yet been thoroughly studied. The aim of this prospective study is to analyze how ozone therapy modulates the expression of certain genes and its impact on epigenetic clocks, which could help predict pain response.

NCT Number	NCT06816095
Lead Sponsor	Bernardino Clavo, MD, PhD Collaborators: Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Fundación DISA, Canary Islands, Spain, Council of Gran Canaria
Conditions	Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy, Gynecological Cancers
Enrollment	40 participants
Start Date	2025-02-10
Primary Completion	2027-02-14 (estimated)
Study Completion	2027-08-14 (estimated)
Updated on ClinicalTrials.gov	2025-02-12