Pharmacogenetics of Response to Sitagliptin (PRS)

This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes. We are asking for healthy, non-diabetic volunteers to participate in this 7-week study. If you agree to participate, you will take part in 2 clinic visits that are 4-6 weeks apart. At the clinic visits you will have an oral glucose tolerance test (OGTT) and other blood tests to see how your body processes glucose (sugar). An OGTT is a test in which your drink glucose and then blood samples are taken afterward at specific time points to measure glucose and insulin in your blood. Each clinic visit will last about 5 hours.

NCT Number	NCT06813014
Lead Sponsor	University of Maryland, Baltimore
Conditions	Diabetes
Enrollment	400 participants
Start Date	2026-12
Primary Completion	2031-11 (estimated)
Study Completion	2032-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-18