Can Blood Biomarkers of Inflammation and BDNF be Used to Assess the Effectiveness of Collagen Mesotherapy in Chronic CMPS?

The aim of the study is to assess the concentration of anti-inflammatory markers after the use of cervical spine mesotherapy in the course of pain syndrome. The study is randomized. Patients will be divided into two groups: A - mesotherapy using injectable type I collagen, B - mesotherapy using 1% lignocaine. The mesotherapy procedure will be performed five times, at weekly intervals. Blood will be collected before the start of mesotherapy, a week after its completion and after 3 months of follow-up. In addition, the effectiveness and safety of mesotherapy of the cervical spine will be assessed.

NCT Number	NCT06807177
Lead Sponsor	National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Conditions	Myofascial Pain Syndrome - Neck, Spondyloarthrosis, Neck Pain, Cervical Pain
Enrollment	40 participants
Start Date	2025-01-08
Primary Completion	2025-09-15 (estimated)
Study Completion	2026-01-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-14