Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery

Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects. The most commonly reported complications include nausea, diarrhea, and occasional orthostatic reactions. The increased risk of thromboembolic events associated with the drug is the most serious complication; however, this has not been reported in most clinical studies and remains uncertain. Based on experience from other types of surgeries, tranexamic acid appears to be safe for use without an increased risk of venous thrombosis. To mitigate systemic absorption and minimize undesirable side effects, TXA can be applied topically rather than intravenously, reducing the risk of venous thromboembolism.

NCT Number	NCT06806241
Lead Sponsor	Bezmialem Vakif University
Conditions	Bleeding, Tooth Extraction
Enrollment	20 participants
Start Date	2025-01-01
Primary Completion	2026-03-01 (estimated)
Study Completion	2026-03-10 (estimated)
Updated on ClinicalTrials.gov	2025-06-24