The OSIRIS ECPR Trial

The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal cardiopulmonary resuscitation (ECPR) based approach versus the conventional cardiopulmonary resuscitation (CCPR) approach.

NCT Number	NCT06805344
Lead Sponsor	General University Hospital, Prague Collaborators: Karolinska Institutet, Heinrich-Heine University, Duesseldorf, University Hospital Freiburg, University Medical Centre Ljubljana, Medical University of Vienna, Hospital Vall d'Hebron, Heart Center Leipzig - University Hospital, Aarhus University Hospital, Royal Brompton & Harefield NHS Foundation Trust, Region Hovedstadens Apotek, Ludwig-Maximilians - University of Munich, European Clinical Research Infrastructure Network, Masaryk University, Insel Gruppe AG, University Hospital Bern, University Hospital, Zürich, University of London, Uniwersytet Wrocławski
Conditions	Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation
Enrollment	686 participants
Start Date	2025-02
Primary Completion	2029-06 (estimated)
Study Completion	2030-06 (estimated)
Updated on ClinicalTrials.gov	2025-02-03