Systemic and Tumor Immune Response During Pelvic (Chemo)Radiation and/or Brachytherapy for Cervical Cancer

Radiotherapy result in tumor cell death by creating an immune potentiation effect, but can also lead to long lasting immune suppression. Thus the investigators hypothesize that pelvic and/or para-aortic radiotherapy for cervical cancer affects local tumor immunity as well as systemic immune response that may be instrumental for long term cancer cure. The goal of this observational study is to understand the effect of various radiotherapy dose per fraction, total dose and field volumes of radiation on systemic and tumor immune response in cervical cancer. The outcome of the study would be useful in improving the quality of radiation treatment and in reducing disease recurrence and improving survival in patients with cervical cancer.

NCT Number	NCT06804135
Lead Sponsor	Tata Memorial Hospital
Conditions	Cervical Carcinoma
Enrollment	110 participants
Start Date	2025-10-25
Primary Completion	2029-01-01 (estimated)
Study Completion	2030-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-02-04