Efficacy and Central Mechanisms of Electroacupuncture for Medication Overuse Headache

Acupuncture is commonly used for the prevention of migraine and tension-type headaches, and has been found to be effective in reducing both the frequency and severity of these conditions. However, studies on acupuncture for medication overuse headache (MOH) are limited, and current research has not been able to determine whether its efficacy is due to the actual therapeutic effects of acupuncture or psychological benefits. To address this issue, the investigators have designed a clinical trial to evaluate the efficacy of acupuncture for MOH. In addition, the investigators will explore the regulatory effects of electroacupuncture on central mechanisms in MOH and conduct multi-omics analysis.

NCT Number	NCT06802471
Lead Sponsor	Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Conditions	Medication Overuse Headache, Electroacupuncture
Enrollment	160 participants
Start Date	2025-02-01
Primary Completion	2026-12 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2025-07-16