Energy Metabolism and Acute Effects of Protein Diets in Metabolically Obese Normal Weight Individuals

Asians tend to develop type 2 diabetes (T2D) at lower body mass index (BMI) levels and younger ages compared to other populations. This leads to a longer duration of suffering from long-term complications associated with the disease, ultimately resulting in shorter life expectancy. Notably, approximately 40% of newly diagnosed T2D cases in Asians occur in individuals considered lean, with a BMI reported to be less than 22 kg/m2. This phenomenon is termed the "Metabolically Obese Normal Weight" (MONW) phenotype. MONW individuals are characterized as having a normal body weight but exhibiting obesity-related metabolic disturbances, including excess body fat with ectopic fat deposition, insulin resistance, and dyslipidemia.

NCT Number	NCT06802341
Lead Sponsor	Singapore Institute of Food and Biotechnology Innovation
Conditions	Healthy, Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine, Insulin Sensitivity, Insulin Resistance
Enrollment	24 participants
Start Date	2022-02-01
Primary Completion	2025-02 (estimated)
Study Completion	2025-02 (estimated)
Updated on ClinicalTrials.gov	2025-01-31