Pain Reprocessing Therapy in Post-Operative Knee Pain

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.

NCT Number	NCT06800209
Lead Sponsor	Weill Medical College of Cornell University Collaborators: Hospital for Special Surgery, New York, University of Colorado, Denver, National Institute on Aging (NIA)
Conditions	Pain, Chronic, Knee Pain Chronic
Enrollment	110 participants
Start Date	2025-08-13
Primary Completion	2027-09-30 (estimated)
Study Completion	2028-09-29 (estimated)
Updated on ClinicalTrials.gov	2026-08-05