Clinical Trial

Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation

Study acronym: KME-TBS
Active, Not Recruiting
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Record status
This record was last updated June 25, 2025 (before its estimated July 1, 2025 completion). Its status may not reflect the trial's current state.
Summary
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent- and continuous-theta burst stimulation (iTBS/cTBS) are increasingly used protocols to enhance or suppress M1 excitability, respectively, beyond stimulation. However, the poor reproducibility and high inter-individual variability in responses to TBS protocols are matters of concern. This study will explore whether ketone monoester supplementation can boost TBS efficacy via their mechanistic convergence on Brain-Derived Neurotrophic Factor (BDNF).
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-01-22.
Status change: Recruiting → Active, Not Recruiting 2025-06-18
Trial Details
NCT Number NCT06799260
Lead Sponsor Universiti Putra Malaysia
Collaborators: University of Oxford
Conditions Healthy Young Adult, Neurophysiology
Enrollment 40 participants
Start Date 2024-12-18
Primary Completion 2025-07-01 (estimated)
Study Completion 2025-12-01 (estimated)
Updated on ClinicalTrials.gov 2025-06-25