The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery

Development of a new comprehensive method for perioperative prevention of atrial fibrillation paroxysms in cardiac surgery patients at the hospital stage. It is planned to recruit 70 patients who will undergo pericardial fenestration during the operation using the original technique during coronary artery bypass grafting (Patent No. 2647626 C1 Russian Federation), and will be prescribed colchicine (the drug "Colchicum-dispert") in the perioperative period in order to prevent the development of paroxysms of atrial fibrillation in the postoperative period, and 70 cardiac surgery patients operated on using the standard technique (without performing the pericardial fenestration procedure intraoperatively), receiving non-steroidal anti-inflammatory drugs in the postoperative period.

NCT Number	NCT06798714
Lead Sponsor	Tomsk Cardiology Research Institute
Conditions	Coronary Artery Disease, Atrial Fibrillation, Coronary Artery Bypass Grafting, Colchicine
Enrollment	140 participants
Start Date	2025-01-20
Primary Completion	2025-07-20 (estimated)
Study Completion	2026-02-20 (estimated)
Updated on ClinicalTrials.gov	2025-09-09