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Radiofrequency Ablation Versus Hemithyroidectomy for Small Thyroid Cancers

StatusRecruiting
PhaseNot applicable
Started2025-09-01
View on ClinicalTrials.gov ↗
This is a multicenter randomized controlled trial including patients with small (\<2 cm) suspected or confirmed thyroid cancers. Patients are included after informed consent and randomized to one of two treatments. One treatment is a standard henithyroidectomy and the second treatment is radiofrequency ablation (RFA) of the specific tumor. The investigators will evaluate initial outcome of the allocated treatment, thyroid hormonal function, oncologic safety, quality of life, and treatment costs in a follow-up period of five years after treatment. The overall aim of the study is to improve patient's health by reducing the number of operations on small thyroid cancers. In patients with these small tumors, the long-term adverse outcome may be higher than possible benefits from the operation. For participants undergoing surgical treatment with HT, the investigators will measure final histology and both beneficial and adverse outcome from the operation. For participants undergoing RFA, the investigators expect to reduce the need for thyroid hormonal substitutions, reduce the surgical adverse outcomes, reduce treatment costs and increase QoL without a reduction in oncologic safety and outcome.

Amendment history 3 changes detected by DataLookout

2026-09-16
notable
Recruitment opened
2026-09-16
notable
Primary completion pushed: 2028-02-28 → 2028-06-28
2026-09-16
minor
Completion pushed: 2028-04-01 → 2028-12-01
Trial Details
NCT Number NCT06796348
Lead Sponsor University of Aarhus
Conditions Thyroid Cancer
Enrollment 88 participants
Start Date 2025-09-01
Primary Completion 2028-06-28 (estimated)
Study Completion 2028-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-15