cGMP: Metabolism and Appetite Modulation

Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of patients with phenylketonuria. Therefore, the aim of this project is to study the impact of acute ingestion of casein glycomacropeptide supplemented with amino acids (cCGMP-AAs) alone or in combination with two different meals on amino acid absorption kinetics, glycaemic and insulinemic response, and on acute markers of appetite control. The main findings of this project will bring new insights into the dietary management of these patients, which may lead to improvements in protein substitutes formulations.

NCT Number	NCT06794515
Lead Sponsor	Universidade Nova de Lisboa
Conditions	Healthy
Enrollment	15 participants
Start Date	2025-02-03
Primary Completion	2025-03-28 (estimated)
Study Completion	2025-04-24 (estimated)
Updated on ClinicalTrials.gov	2025-01-27