Clinical Trial

A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma

Study acronym: ABSALON
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The aim of this clinical trial is to investigate whether oral semaglutide can be used to treat open-angle glaucoma. The main question it aims to answer is: Does oral semaglutide safely improve inner retinal function in patients with open-angle glaucoma as measured by the photopic negative response of the electroretinogram. Researchers will compare oral semaglutide to a placebo (a look-alike substance that contains no drug). Participants will: * Take semaglutide or a placebo every day for 6 months. * Visit the clinic 5 times in total for tests and interviews: At baseline (the first day they are included in the study), after 1 month, after 2 months, after 3 months, and after 6 months (the last day they are included in the study).
Trial Details
NCT Number NCT06792422
Lead Sponsor Glostrup University Hospital, Copenhagen
Conditions Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma, Glaucoma
Enrollment 126 participants
Start Date 2025-01
Primary Completion 2028-08 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2025-01-24