Clinical Trial

Effects of Neostigmine-dose on Diaphragmatic Dynamics

Study acronym: DTF/DE/AChE
Not Yet Recruiting Phase 1
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Record status
This record was last updated January 22, 2025 (before its estimated January 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this Randomized Clinical Trial is to compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg/kg) and those receiving full-dose neostigmine (0.08 mg/kg) for neuromuscular blockade reversal. The main questions it aims to answer are: * Does half-dose neostigmine result in similar postoperative diaphragmatic excursion compared to full-dose neostigmine? * Does half-dose neostigmine result in similar diaphragmatic thickening fraction compared to full-dose neostigmine? Researchers will compare patients receiving half-dose neostigmine to those receiving full-dose neostigmine to see if there are differences in postoperative diaphragmatic function, respiratory complications, and recovery. Participants will: * Undergo elective laparoscopic cholecystectomy. * Receive either half-dose or full-dose neostigmine for neuromuscular blockade reversal.
Trial Details
NCT Number NCT06787638
Lead Sponsor Aswan University Hospital
Conditions Diaphragm Ultrasound
Enrollment 50 participants
Start Date 2025-01-25
Primary Completion 2026-01 (estimated)
Study Completion 2026-04 (estimated)
Updated on ClinicalTrials.gov 2025-01-22