Clinical Trial

Extended Clinical Follow up and Biospecimen Collection for Patients Enrolled in TAILORx and RxPONDER: A Companion Protocol

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Summary
The purpose of this study is to retrieve tissue samples from individuals with breast cancer who previously enrolled on the PACCT-1 (TAILORx) or S1007 (RxPONDER) trials and experiences a recurrence of their cancer (Cohort 1, 2, and 3), and/or the tumor initially removed at surgery in patients previously enrolled in step 1 of S1007 (RxPONDER) and found to have a high Recurrence Score of 26-100 (Cohort 3) but not followed on the study after that point. The tissue will be used for future research designed to understand why breast cancer recurs despite hormonal therapy or chemotherapy plus hormonal therapy.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-01-21.
Trial Details
NCT Number NCT06786585
Lead Sponsor Eastern Cooperative Oncology Group
Collaborators: United States Department of Defense
Conditions Breast Cancer
Enrollment 600 participants
Start Date 2025-06
Primary Completion 2027-04 (estimated)
Study Completion 2028-04 (estimated)
Updated on ClinicalTrials.gov 2025-05-30