Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT)

This clinical trial aims to evaluate the effect of different types of tDCS modulation with mCIMT in improving affected upper-limb motor function for stroke patients. The main question it seeks to answer: Which type of tDCS (bi-hemispheric, anodal, or cathodal) combined with the mCIMT program leads to greater improvement in affected upper-limb function in patients with stroke? Researchers will compare these three types of tDCS to a sham tDCS. To see which kind of tDCS protocol combined with the mCIMT program will be more effective in improving affected upper-limb function for stroke patients. Participants will: 1. Participants will receive 12 sessions of mCIMT combined with tDCS or mCIMT alone. 2. Visit the clinic three times a week for four weeks. 3. Participants will do fMRI and TMS before and after the program and three times of assessment before and after two weeks after the program.

NCT Number	NCT06786000
Lead Sponsor	King Saud University Collaborators: King Saud Medical City, King Fahad Medical City
Conditions	Stroke, Hemiparesis of the Upper Limb Following Stroke, Stroke Rehabilitatiom
Enrollment	300 participants
Start Date	2023-04-11
Primary Completion	2025-04-11 (estimated)
Study Completion	2025-04-11 (estimated)
Updated on ClinicalTrials.gov	2025-01-22