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A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder

Name: A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder — clinical trial record (NCT06785012)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: Moonlight-1

StatusCompleted

PhasePhase 2

SponsorJanssen Research & Development, LLC

Started2024-12-26

View on ClinicalTrials.gov ↗

The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant effects) and how well it is tolerated as compared to placebo on reducing the symptoms of depression in participants with major depressive disorder (MDD).

Amendment history 4 changes detected by DataLookout

2026-08-29

Trial completed

2026-07-07

Completion pushed: 2026-06-26 → 2026-08-10

2026-06-06

Trial status changed: Recruiting → Active, Not Recruiting

2026-05-09

Enrollment reduced: 124 → 100 participants

Trial Details

NCT Number	NCT06785012
Lead Sponsor	Janssen Research & Development, LLC
Conditions	Depressive Disorder, Major
Enrollment	107 participants
Start Date	2024-12-26
Primary Completion	2026-06-25 (estimated)
Study Completion	2026-08-10 (estimated)
Updated on ClinicalTrials.gov	2026-08-28