Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction

The main purpose of this study is to determine which type of medication, sufentanil or methadone, is better at controlling pain during and, more importantly, after surgery in patients undergoing a head and neck dissection with free flap or rotational tissue reconstruction. Prior to their operation, subjects will be randomized to receive either Sufentanil or Methadone. After surgery, research staff will obtain information about recovery and pain levels.

NCT Number	NCT06784999
Lead Sponsor	Indiana University
Conditions	Free Flap Reconstruction
Enrollment	128 participants
Start Date	2025-01-10
Primary Completion	2027-11-04 (estimated)
Study Completion	2027-11-04 (estimated)
Updated on ClinicalTrials.gov	2026-05-01