The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity

This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \>22% body fat for males and \>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.

NCT Number	NCT06784544
Lead Sponsor	United States Army Research Institute of Environmental Medicine Collaborators: Pennington Biomedical Research Center
Conditions	Sleep, Inadequate, Energy Deficit, Iron Absorption, High Physical Activity
Enrollment	24 participants
Start Date	2025-05
Primary Completion	2025-11 (estimated)
Study Completion	2025-11 (estimated)
Updated on ClinicalTrials.gov	2025-01-20