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Investigation of Objective Cognitive Effort in Neuropsychological Evaluation of Psychotic Disorders

Study acronym: INVESTIGECCO
StatusUnknown
PhaseNot specified
Started2025-01-27
View on ClinicalTrials.gov ↗
Record status
This record was last updated January 20, 2025 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2026-09-06
minor
Trial status changed: Not Yet Recruiting → Unknown
Psychotic disorders are characterised by a heterogeneity of symptoms, including cognitive disorders, which predict functional outcome. To date, the evaluation of cognitive functions essentially measures performance. Cognitive effort and the influence of psychological factors are rarely considered. Based on the principle of energy conservation, the Motivational Intensity Theory (MIT) allows to test cognitive effort independently of performance, by measuring cardiovascular reactivity, as well as controlling for psychological factors (e.g., mood, fatigue, anxiety). The main aim of this study is to investigate in a memory task the interaction between cognitive effort, performance and psychological factors in individuals with psychotic disorders compared to a non-clinical group, based on the predictions of the MIT. This study will provide insights into the nature of cognitive impairment in psychotic disorders: primary or secondary to motivational (effort) or psychological (mood, fatigue, anxiety) difficulties.
Trial Details
NCT Number NCT06782672
Lead Sponsor University Hospital, Montpellier
Collaborators: fondation john bost
Conditions Schizophrenia, Psychotic Disorders, Cognitive Impairment, Motivation
Enrollment 100 participants
Start Date 2025-01-27
Primary Completion 2026-07-01 (estimated)
Study Completion 2026-07-01 (estimated)
Updated on ClinicalTrials.gov 2025-01-20