Development of Preclinical Models Derived From Tumors With a Molecular Abnormality of Interest to Test Their Sensitivity to New Anti-tumor Therapies.

This study aims to collect tumor samples from patients carrying a mutation of interest to develop a cell culture technique for "spheroids. The goal is to use these spheroids to model responses to anticancer treatments. Various therapeutic molecules can be tested on these spheroids, enabling the evaluation of the potential of new molecules or the activity of existing ones specifically on the tumor (bearing the mutation of interest) from which the spheroid was developed. Tumor samples will be collected as part of biopsies or surgeries conducted during routine patient care.

NCT Number	NCT06782451
Lead Sponsor	Centre Antoine Lacassagne
Conditions	Neoplasm Malignant
Enrollment	50 participants
Start Date	2025-05-02
Primary Completion	2030-07-02 (estimated)
Study Completion	2030-07-02 (estimated)
Updated on ClinicalTrials.gov	2026-07-20