Clinical Trial

Supplemental High Flow Oxygen to Reduce Infections in Obese Gynecological Cancer Patients

Study acronym: SAFE
Recruiting
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Record status
This record was last updated January 17, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The incidence of surgical-site infection (SSI) and complications related to wound healing reaches 10-20% of gynecological cancer patients. Each complication may dramatically prolong the hospitalization period and increase the economic burden of hospital care. Appropriate wound care and tissue oxygenation are of special importance for wound healing. Assuming adequate perfusion, the easiest, safest, and most effective way to improve tissue oxygenation is to increase the fraction of inspired oxygen. However, there is considerable controversy as to whether supplemental oxygen actually reduces SSI and healing-related complications as to date, there is absence of relevant data.
Trial Details
NCT Number NCT06780813
Lead Sponsor National and Kapodistrian University of Athens
Conditions Supplemental Oxygen, Gynecological Cancer, Surgical Site Infections
Enrollment 400 participants
Start Date 2025-01-10
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-05-01 (estimated)
Updated on ClinicalTrials.gov 2025-01-17