Physical Activity and Insulin Sensitivity Dynamics

The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. Furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. This will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.

NCT Number	NCT06776094
Lead Sponsor	University of Copenhagen
Conditions	Insulin Sensitivity
Enrollment	8 participants
Start Date	2025-05-05
Primary Completion	2025-08-26 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-02