Clinical Trial

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

Recruiting
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Summary
Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose tissue health and systemic messengers, regulators and mediators of cardiometabolic health and disease with obesity. The investigators hypothesize that elevated Ad-EVs in adults with obesity will be negatively associated with endothelium-dependent vasodilation. Furthermore, the investigators hypothesize that in adults with obesity, intentional weight loss-induced reduction in circulating Ad-EVs is associated with greater endothelium-dependent vasodilation.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-01-09.
Trial Details
NCT Number NCT06776081
Lead Sponsor University of Colorado, Boulder
Conditions Obesity, Weight Loss
Enrollment 84 participants
Start Date 2024-07-01
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-28