Integrated Approach in Frail Older People with Atrial Fibrillation

The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an improvement in clinical conditions and quality of life compared to usual clinical care. The i-ABC group in AFFIRMO will follow the ABC pathway, focused on three domains: avoid stroke with anticoagulation (with optimized VKA or label-adherent DOAC use); better symptom management; and optimized management of associated cardiovascular and non cardiovascular comorbidities. The study will be conducted in Bulgaria, Denmark, Italy, Romania, Serbia and Spain .

NCT Number	NCT06775028
Lead Sponsor	Heart Care Foundation Collaborators: Aalborg University, University of Belgrade, Universidad de Murcia, Carol Davila University of Medicine and Pharmacy, Plovdiv Medical University, University of Liverpool
Conditions	Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure, COPD, Peripheral Arterial Disease, CKD, Diabetes Mellitus +2 more
Enrollment	1,250 participants
Start Date	2024-04-11
Primary Completion	2026-01-31 (estimated)
Study Completion	2026-01-31 (estimated)
Updated on ClinicalTrials.gov	2025-01-14