Clinical Trial

Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery

Not Yet Recruiting
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Record status
This record was last updated January 13, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension. However, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.
Trial Details
NCT Number NCT06771232
Lead Sponsor University of Chile
Conditions Intracranial Pressure Increase, Mechanical Ventilation Complication
Enrollment 20 participants
Start Date 2025-01-01
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2025-01-13