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Prolonged Compression Following Foam Sclerotherapy

Study acronym: ProCOMFFS
StatusActive, Not Recruiting
PhaseNot applicable
Started
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Record History

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  1. Minor Study completion pushed from Jul 31, 2026 to Dec 31, 2026
    • Eligibility criteria expanded, about 11 words
    • Secondary endpoints: details revised at 12 of 20 entries
    • Site details revised
  2. Minor Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v3
  3. Minor Secondary endpoints: details revised at 1 of 20 entries
    • Site details revised
    • Eligibility criteria expanded, about 4 words
    v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Foam-form sclerotherapy is an effective method for eliminating varicose veins, which can be used alone or in combination with other interventions (laser or radiofrequency ablation, cyanoacrylate glue embolization) in the treatment of chronic venous disease of the lower limbs. Sclerotherapy is utilized to address both primary and recurrent varicose veins, and it is associated with a low rate of complications. Among the adverse effects, the most common is skin hyperpigmentation (darkening of the skin with the formation of stripes of shades of brown directly above the treated veins), with an occurrence rate reaching 6-53% within the first month following the procedure. Still, it resolves independently in 70% of cases within 6 months. An essential component of sclerotherapy is compression therapy through bandages or medical stockings, which helps accelerate the absorption of veins and improve the aesthetic results of treatment. Meanwhile, the optimal duration for wearing compression stockings after performing foam-form sclerotherapy of varicose tributaries has not been established.
Trial Details
NCT Number NCT06766968
Lead Sponsor Pirogov Russian National Research Medical University
Conditions
(from sponsor)
Chronic Venous Disorder, Varicose Veins Leg
Related terms Varicose Veins
Enrollment 140 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov