Characterizing the Retinal Microvasculature in Patients with Fabry Disease: a Prospective Observational Study

This study aims to gain a deeper understanding of endothelial dysfunction in patients with Fabry disease through a prospective study of the retinal microvasculature and to identify an objective, non-invasive marker to assess disease severity and cardiovascular risk in patients. The main questions addressed are: Do dynamic and static retinal vessel analysis parameters differ from those in healthy individuals? Can these parameters predict cardiovascular and/or Fabry-related events during follow-up? Do these parameters change during follow-up in patients with a non-stable disease?

NCT Number	NCT06758648
Lead Sponsor	Technical University of Munich Collaborators: Takeda
Conditions	Fabry Disease, Endothelial Dysfunction, Microvasculature
Enrollment	63 participants
Start Date	2020-06-25
Primary Completion	2021-09-01 (estimated)
Study Completion	2025-11-01 (estimated)
Updated on ClinicalTrials.gov	2025-01-06