Histiocytosis and Inflammatory Manifestations in Patients with H Syndrome

H syndrome is a rare genetic disorder predisposing to histiocytosis. Our knowledge of the clinical spectrum of these patients is based on case reports and small patient series. Patients with H syndrome have been treated with a range of immunomodulatory and chemotherapeutic agents, with limited success. We aim to comprehensively assess the clinical manifestations and patterns of treatment response in a multinational cohort of patients with H syndrome.

NCT Number	NCT06742073
Lead Sponsor	Rabin Medical Center
Conditions	H Syndrome
Enrollment	120 participants
Start Date	2024-11-01
Primary Completion	2026-07-01 (estimated)
Study Completion	2026-08-01 (estimated)
Updated on ClinicalTrials.gov	2024-12-19