Mechanisms of Stimulation for Pain Alleviation

This is a mechanistic randomized controlled trial of patients with chronic neuropathic pain (CNP) in the upper extremities, lower back, pelvis, and lower extremities, randomized to conventional medical management (CMM) or combined CMM and peripheral nerve stimulation therapy (PNS+CMM). Our goal is to compare treatment outcomes and trial response rate across the control and interventional device groups.

NCT Number	NCT06741579
Lead Sponsor	Stanford University Collaborators: National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), University of Kansas Medical Center
Conditions	Peripheral Nerve Stimulation, Chronic Neuropathic Pain, Chronic Neuropathic Pain (Below the Shoulders)
Enrollment	148 participants
Start Date	2025-09-26
Primary Completion	2028-08 (estimated)
Study Completion	2028-11-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-23