Clinical Trial

Relationship Between Pulse Pressure and Stroke Volume in the Critically Ill Patients: The ANDROMEDA-PEGASUS Study

Recruiting
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Record status
This record was last updated May 29, 2025 (before its estimated October 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this study is to assess the predictive capacity of pulse pressure to estimate stroke volume, as assessed by bedside echocardiography in critically ill patients. We hypothesize that pulse pressure will be able to adequately detect low values of stroke volume, and to track changes of stroke volume during commonly used dynamic cardiovascular interventions. Pulse pressure transduced from an arterial line will be measured simultaneously with left ventricular outflow tract velocity time integral in a broad range of critically ill patients. Ancillary clinical, hemodynamic and echocardiographic data will also be registered.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-12-16.
Status change: Not Yet Recruiting → Recruiting 2025-05-27
Trial Details
NCT Number NCT06737614
Lead Sponsor Pontificia Universidad Catolica de Chile
Collaborators: Erasmus Medical Center, Fundacion Clinica Valle del Lili, Hospital do Coracao
Conditions Critical Illness
Enrollment 1,500 participants
Start Date 2025-05-01
Primary Completion 2025-10-30 (estimated)
Study Completion 2026-01-30 (estimated)
Updated on ClinicalTrials.gov 2025-05-29