Clinical Trial

The Effect of Exercise on the Brain in Type 2 Diabetes

Study acronym: SAINT
Recruiting
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Summary
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients. The main question it aims to answer is: What is the effect of exercise training of high vs. moderate intensity on brain metabolism, brain perfusion, and cognition in type 2 diabetes? Researchers will compare the exercise training groups to a control group without exercise training to determine the effect of exercise training on the brain in type 2 diabetes. Participants will exercise for 6 months, 3 times per week. Before and after these 6 months, they will undergo: * a brain MRI scan * cognitive tests * blood sampling
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-12-13.
Status change: Enrolling by Invitation → Recruiting 2026-03-30
Trial Details
NCT Number NCT06734546
Lead Sponsor Hasselt University
Collaborators: Universitaire Ziekenhuizen KU Leuven, Jessa Hospital, Research Foundation Flanders
Conditions Type 2 Diabetes
Enrollment 75 participants
Start Date 2024-11-08
Primary Completion 2027-08 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-03-31