ChemoRT With and Without Dental Stent for Taste Protection in NPC Patients

Primary objective: Evaluate and compare incidence of acute and long-term taste dysfunction in chemoradiation plus dental stent group vs. chemoradiation group, using objective-measured taste strip test, and patient-reported taste ability and toxicity. Secondary objectives: 1. Evaluate and compare incidence of acute and long-term toxicities (excluding taste) and patient-reported quality of life between chemoradiation plus dental stent group and chemoradiation group. 2. Evaluate and compare tumor response, overall survival, and failure-free survival between chemoradiation plus dental stent group and chemoradiation group. 3. Analyze dosimetric parameters of taste bud bearing tongue mucosa, ipsilateral/ contralateral parotid and submandibular glands extracted from RT plans and correlate with taste impair

NCT Number	NCT06733948
Lead Sponsor	National University Hospital, Singapore Collaborators: Singapore Institute of Food and Biotechnology Innovation
Conditions	Nasopharyngeal Carcinoma
Enrollment	50 participants
Start Date	2024-09-24
Primary Completion	2025-12 (estimated)
Study Completion	2026-05 (estimated)
Updated on ClinicalTrials.gov	2024-12-13