Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room

The best hypnotic choice to optimize the balance between good intubation condition quality and hemodynamic stability during RSI performed in the operating theatre remained to be investigated. Therefore, a randomized study evaluating the efficacy of propofol, ketamine, and a combination of both is appropriate. So, we designed the HyPnotiKs randomized controlled study to investigate the efficacy of these hypnotic drugs in patients undergoing RSI in the operating theatre. The primary endpoint will be the successful tracheal intubation at the first attempt without major arterial hypotension event.

NCT Number	NCT06733129
Lead Sponsor	Nantes University Hospital
Conditions	Rapid Sequence Induction
Enrollment	1,218 participants
Start Date	2025-04-14
Primary Completion	2027-04-14 (estimated)
Study Completion	2027-04-30 (estimated)
Updated on ClinicalTrials.gov	2025-12-02