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Subthreshold Vestibular Stimulation as a Strategy for Rehabilitation

StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Jan 1, 2026 to Feb 9, 2026
    • Site details revised
    v4
  2. Enrollment target: 30 to 48v3 Show 6 more changesShow less
    • Primary endpoints revised (2)
    • Interventions: Balance Training (Behavioral), Subthreshold Vestibular Conditioning (Behavioral) to Balance Training (Behavioral), Balance Training Plus Subthreshold Conditioning (Other), Subthreshold Vestibular Conditioning (Behavioral)
    • Secondary endpoints shortened, about 10 words
    • Study description shortened, about 282 words
    • Study arms: 3 to 1
    • Eligibility criteria expanded, about 3 words
  3. Start date: Jul 1, 2025 to Jan 1, 2026v2 Show 4 more changesShow less
    • Secondary endpoints: details revised at 1 of 2 entries
    • Site contact updated
    • Eligibility criteria expanded, about 1 word
    • Study description expanded, about 2 words
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The nervous system responds to changes in external or internal conditions by altering the behavior of neurons through multiple forms of neural plasticity. A specific form of plasticity, "homeostatic plasticity", stabilizes neural activity by driving the excitability of neurons toward a "set-point" level of activity. Over the last six years, new data have come to light showing that the vestibular system also possess a robust capacity to modulate sensitivity to self-motion cues in response to prolonged periods of motion. Collectively, these studies have demonstrated a capacity to use motion perturbations (i.e., low, or high levels of vestibular stimulation) to dynamically adjust the sensitivity of the vestibular system on both the single neuron and behavioral levels. The ability to use subthreshold motion stimuli to drive plasticity in the vestibular system motivates this study. The investigators aim to determine the impact of subthreshold motion on (a) balance performance and (b) balance training in individuals with peripheral vestibular hypofunction.
Trial Details
NCT Number NCT06732440
Lead Sponsor Creighton University
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions
(from sponsor)		 Vestibular Hypofunction, Bilateral Vestibular Hypofunction, Presbyvestibulopathy, Healthy Controls
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov