Clinical Trial

Non-steroidal Anti-inflammatory Drugs in Pleurodesis

Study acronym: KETOTHORAX
Recruiting Phase 2
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Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence. The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2024-12-09; most recent amendment 2025-03-18.
Status change: Not Yet Recruiting → Recruiting 2025-03-18
Status change: Recruiting → Not Yet Recruiting 2025-01-17
Trial Details
NCT Number NCT06731647
Lead Sponsor Centre Hospitalier Universitaire, Amiens
Collaborators: Centre Hospitalier VALENCIENNES, Clinique Victor Pauchet, University Hospital, Rouen
Conditions Non-steroidal Anti-inflammatory Drugs, Pleurodesis, Pneumothorax, Pain Management
Enrollment 358 participants
Start Date 2025-02-01
Primary Completion 2027-11 (estimated)
Study Completion 2028-11 (estimated)
Updated on ClinicalTrials.gov 2025-03-19