Clinical Trial

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

Recruiting

Summary

The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.

Protocol Amendment History 9 changes

critical Enrollment reopened 2026-08-13

notable Enrollment increased: 10 -> 120 participants 2026-08-13

notable Sponsor changed: Indiana University -> University of Cincinnati 2026-08-13

notable Primary completion pushed: 2026-04-02 -> 2030-06-28 2026-08-13

minor Completion pushed: 2027-04-02 -> 2031-06-28 2026-08-13

critical Enrollment closed, study ongoing 2026-08-01

notable Enrollment reduced: 120 -> 10 participants 2026-08-01

notable Primary completion moved earlier: 2029-08-31 -> 2026-04-02 2026-08-01

minor Completion moved earlier: 2030-08-30 -> 2027-04-02 2026-08-01

Trial Details

NCT Number	NCT06725550
Lead Sponsor	University of Cincinnati
Conditions	Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
Enrollment	120 participants
Start Date	2026-07-01
Primary Completion	2030-06-28 (estimated)
Study Completion	2031-06-28 (estimated)
Updated on ClinicalTrials.gov	2026-08-12