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Transcutaneous Vagus Nerve Stimulation for Attention and Memory

Study acronym: taVNS
StatusNot Yet Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Start date: Aug 2026 to Dec 2026 Trial status changed: Recruiting → Not Yet Recruiting · Eligibility criteria expanded, about 17 words · Secondary endpoints: details revised at 1 of 1 entry · 3 more Show 6 more changesShow less
    • Trial status changed: Recruiting → Not Yet Recruiting
    • Eligibility criteria expanded, about 17 words
    • Secondary endpoints: details revised at 1 of 1 entry
    • Site details revised at 2 of 2 sites
    • Publications: details revised at 15 of 16 entries
    • Study description expanded, about 4 words
  2. Primary completion date: Feb 2026 to Jul 2027 Start date: Nov 2025 to Aug 2026 · Completion date: Feb 2026 to Aug 2027 · Site details revised at 2 of 2 sitesv5 Show 3 more changesShow less
    • Start date: Nov 2025 to Aug 2026
    • Completion date: Feb 2026 to Aug 2027
    • Site details revised at 2 of 2 sites
  3. Primary and study completion dates: Dec 2025 to Feb 2026 Start date: Oct 2025 to Nov 2025v4 Show 1 more changeShow less
    • Start date: Oct 2025 to Nov 2025
  4. Trial status: Not Yet Recruiting to Recruiting Start date: Jan 15, 2025 to Oct 2025 · Study sites: 1 to 2 · Primary and study completion dates: Sep 2025 to Dec 2025v3 Show 3 more changesShow less
    • Start date: Jan 15, 2025 to Oct 2025
    • Study sites: 1 to 2
    • Primary and study completion dates: Sep 2025 to Dec 2025
  5. Primary endpoint revisedv2 See this version in full on ClinicalTrials.gov ↗
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and depression and/or posttraumatic stress disorder (PTSD). The study seeks to answer two main questions: 1. Can active taVNS improve attention and memory compared to sham (placebo) stimulation? 2. Does taVNS affect heart rate variability (HRV)? taVNS delivers a gentle electrical current to the vagus nerve through electrodes placed on the ear, targeting brain areas involved in attention and memory without requiring surgery. This study uses a crossover design, meaning all participants will experience two sessions: one with active taVNS and one with sham stimulation. The sham session feels similar but does not deliver actual stimulation, allowing researchers to compare the two and understand taVNS's effects on the brain. In a single visit, participants will: * Complete eligibility screening (questionnaires and vital signs). * Undergo two sessions (one active and one sham), randomly assigned. * Perform attention tasks before and after each session. * Have their heart rate monitored during the sessions. The findings will help determine whether taVNS could be an effective treatment for improving attention and memory in veterans with TBI.
Trial Details
NCT Number NCT06723743
Lead Sponsor Baylor College of Medicine
Collaborators: Michael E. DeBakey VA Medical Center
Conditions Traumatic Brain Injury (TBI) Patients
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov