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NCT06722807 · ClinicalTrials.gov record · last posted 2026-07-30

ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses

Study acronym: CASPIAN
StatusSuspended
PhaseNot applicable
Started2025-06-10
View on ClinicalTrials.gov ↗
Why the trial stopped
Interim analysis
from the ClinicalTrials.gov record
During partial nephrectomy surgery, efforts at minimizing ischemia while maximizing renal parenchymal volume are desirable to preserve renal function1,2. Not only clamping of the hilum but the renorrhaphy portion of the procedure also can have a significant negative impact on renal function3-5. It is possible to perform this procedure without clamping the hilum and also without formal renorrhaphy. However robust prospective formal evaluation of safety, risks, and potential benefits and whether or not the technique can be employed in a generalized fashion has not been studied. Demonstration of safety and generalizability may open a whole new avenue of approaching nephron sparing and renal function sparing kidney surgery and decrease potential risks for long term kidney disease in patients with renal masses. This study will investigate the safety, efficacy, and generalizability of the use of clampless, sutureless partial nephrectomy in the treatment of renal cell carcinoma.

Protocol amendment history 2 changes detected by DataLookout

2026-07-31
Recruitment suspended
2026-07-31
Recruitment suspended: Interim analysis
Trial Details
NCT Number NCT06722807
Lead Sponsor University of Florida
Conditions Renal Cell Carcinoma (RCC)
Enrollment 59 participants
Start Date 2025-06-10
Primary Completion 2026-08 (estimated)
Study Completion 2027-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-30