Indonesian Study of Vonoprazan Vs Esomeprazole in Erosive Esophagitis

The goal of this clinical trial is to compare drug vonoprazan vs esomeprazole effectiveness to relieve early symptoms in Erosive Esophagitis Patients. It will also learn about the safety of both modalities. The main questions it aims to answer are: How does the effectiveness of Vonoprazan compare with Esomeprazole in improving early symptoms of erosive esophagitis patients in the Indonesian population? Researchers will compare drug vonoprazan to a esomeprazole with a look-alike packaging to see their effect to reduce early symptoms of erosive esophagitis. Participants will: * Take drug vonoprazan 20mg or esomeprazole 40mg one time every day for 2 weeks * Visit the clinic once every weeks for followup (Gastro Esophageal Reflux Disease-Quetionnaire measurement) * Keep a diary of their adverse effect occurence and every variable data based on Gastro Esophageal Reflux Disease-Questionnaire.

NCT Number	NCT06720610
Lead Sponsor	Indonesia University
Conditions	Erosive Esophagitis
Enrollment	216 participants
Start Date	2024-12-09
Primary Completion	2025-04-25 (estimated)
Study Completion	2025-06-27 (estimated)
Updated on ClinicalTrials.gov	2024-12-17