Immunohistochemical Algorithm for the Diagnosis and Classification of Hepatocellular Carcinomas With TERT, TP53 and CTNNB1 Mutation

The presence of certain mutations in HCC, such as TERT and TP53, have a suspected or proven prognostic role in resected patients, but lack a morphological or immunophenotypic counterpart, which would allow us to define which tumours are rationally candidate for molecular biology analysis. The identification of a histological and immunohistochemical algorithm to determine which HCCs to take to NGS for prognostic purposes will save time and economic costs in the laboratory by rationalising available resources. In the future, the application of the immunohistochemical and molecular algorithm on biopsy could allow better prognosis and predictivity even before surgery/therapy.

NCT Number	NCT06718153
Lead Sponsor	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Conditions	Hepatic Cancer, Hepatic Resection
Enrollment	100 participants
Start Date	2024-10-23
Primary Completion	2025-05-13 (estimated)
Study Completion	2025-06 (estimated)
Updated on ClinicalTrials.gov	2024-12-05