High Flow Nasal Oxygen Therapy an Implementation Study in Pediatric Wards

The purpose of this study is to prospectively evaluate the process of implementing HFNO in several MSF projects, varying according to geographical and programmatic contexts, population, health structures, human resources, and management. It will generate evidence on the operational feasibility (in terms of human resources, equipment, logistics and costs) of integrating HFNO into PICU standard of care, as well as on the users' and caregivers' perspectives on HFNO and on the children clinical outcomes observed where HFNO is implemented. This relevant information will guide MSF in the decision making of scaling up HFNO therapy in its projects.

NCT Number	NCT06715423
Lead Sponsor	Epicentre Collaborators: MOH Afghanistan, MOH Bangladesh, MOH Sierra Leone, MOH Yemen, MSF Médecins Sans Frontières Belgium, MSF Médecins Sans Frontières France, Fisher and Paykel Healthcare
Conditions	Moderate Respiratory Distress, Severe Respiratory Distress
Enrollment	960 participants
Start Date	2025-01
Primary Completion	2025-12 (estimated)
Study Completion	2025-12 (estimated)
Updated on ClinicalTrials.gov	2025-01-30