Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery

Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.

NCT Number	NCT06713733
Lead Sponsor	B.P. Koirala Institute of Health Sciences
Conditions	Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Enrollment	50 participants
Start Date	2024-09-25
Primary Completion	2024-12-25 (estimated)
Study Completion	2025-01-25 (estimated)
Updated on ClinicalTrials.gov	2024-12-03