InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease

This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.

NCT Number	NCT06713512
Lead Sponsor	Guy's and St Thomas' NHS Foundation Trust
Conditions	Chronic Obstructive Lung Disease, Respiratory Ilness, Estrogen Deficiency, Asthma
Enrollment	100 participants
Start Date	2024-12-01
Primary Completion	2026-01-01 (estimated)
Study Completion	2028-11-01 (estimated)
Updated on ClinicalTrials.gov	2024-12-03