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NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia

Study acronym: NT-NOA
StatusActive, Not Recruiting
PhasePhase 1/2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 17, 2026 (before its estimated August 2026 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fieldsv6
  2. Primary completion date: Aug 2025 to Aug 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Jan 2026 to Aug 2026
    • Site details revised
    v5
  3. Eligibility criteria expanded, about 8 wordsv4
  4. Eligibility criteria revised
    • Site contact updated
    v3
  5. Trial status: Active, Not Recruiting to Recruitingv2 Show 4 more changesShow less
    • Start date: Oct 1, 2024 to Mar 1, 2025
    • Interventions: Denosumab (Prolia) (Drug) to Denosumab (Prolia) (Drug), Letrozole (Aromatase Inhibitors) (Drug)
    • Study description expanded, about 37 words
    • Site details revised
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker.
Trial Details
NCT Number NCT06706414
Lead Sponsor Martin Blomberg Jensen
Conditions
(from sponsor)		 Infertility, Male
Related terms Infertility, Male
Enrollment 16 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov