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Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery

StatusCompleted
PhaseNot applicable
Started
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Record History

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  1. Trial completed Show 5 more changesShow less
    • Primary completion date changed from estimate of Dec 25, 2025 to Mar 13, 2025
    • Study completion date changed from estimate of Dec 30, 2025 to Mar 13, 2026
    • Eligibility criteria expanded, about 28 words
    • Secondary endpoints: details revised at 1 of 4 entries
    • Site details revised
  2. Re-verified, no change to tracked fieldsv3
  3. Start date changed from estimate of Nov 25, 2024 to Dec 3, 2024v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Prevention of postoperative pain is essential for the recovery of esophageal surgery. Epidural analgesia is a traditional and standard perioperative pain management for these patients. Beneficials of epidural analgesia have been widely established. However, there are still several potential disadvantages such as perioperative hypotension, failure of administration, rare but serious neurological complications. Ultrasound-guided regional nerve block has become a widely used technique due to its low degree of trauma and precise target of action. In combined with liposome bupivacaine (LB), a new long-acting local anesthetic, was proven to have a maximum duration of 72 hours, thus improving postoperative analgesia, reducing opioid consumption, and enhancing patient satisfaction. The aim of this study was to evaluate the efficacy of TPVB liposomal bupivacaine (LB) or plane bupivacaine (SB) for Overall Benefit of Analgesic Score (OBAS) after esophageal surgery.
Trial Details
NCT Number NCT06704698
Lead Sponsor Zhejiang Cancer Hospital
Conditions
(from sponsor)		 Pain Syndrome, Dizziness, Vomiting, Itching, Sweet Syndrome, Cold, Satisfaction, Patient
Related terms Common Cold, Dizziness, Patient Satisfaction, Pruritus, Somatoform Disorders, Sweet Syndrome, Vomiting
Enrollment 132 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov